Custom Peptide Synthesis Services
Custom Peptide Synthesis — Versatile Chemistries, Faster Progress
PeptARx peptide discovery platform delivers bespoke peptide design and synthesis across modalities, lengths, and complexities—optimized for your discovery timelines and downstream development.
What We Synthesize
- Architectures & Modalities: Linear, branched, cyclic, stapled, and bicyclic peptides, including PEGylated formats and advanced peptidomimetics—engineered for both custom and library-based discovery programs.
- Challenging Sequences: Disulfide rich, boronic acid, conformationally constrained.
- Backbone Engineering: DAAs, N-methylations, unnatural AAs, THF amino acids in SPPS for stability & bioactivity.
- Long Peptides & Protein Fragments: NCL/KAHA ligation for extended sequences (>150 AAs).
Linear Peptide Synthesis
- Synthesis Methods:
- Fmoc Solid-Phase Peptide Synthesis (SPPS)
- Fragment Coupling
- Chemical Ligation
- Experience Highlights:
- Expertise in synthesizing linear peptides up to >150 amino acids
- Annual delivery of 5,000+ peptides including:
- Linear peptides and modified peptides
- Complex formats such as PNAs, peptoids, branched peptides, dendrimers, peptidomimetic peptides
Modified Peptide Synthesis (Discovery Grade Customization)
PeptARx offers a full spectrum of peptide modification strategies to optimize stability, functionality, and performance for your program:
- Terminal Engineering: Precise N-terminal and C-terminal modifications for enhanced peptide integrity
- Smart Labeling: Fluorescent dyes, biotin tags, and isotope incorporation for imaging and analytical studies
- PEGylation & Conjugation: Improve solubility, pharmacokinetics, and targeted delivery
- Biological Mimics: Late-stage modifications such as phosphorylation, sulfation, and glycosylation, oxidative folding
- Chelator Integration: DOTA/NOTA for radiolabeling and diagnostic applications
- H (free amine)
- Acetylation
- Fmoc
- CBZ
- Bz
- Pyr
- Biotinylation
- Lipid tail
- Dye and fluorescent labeling
- -OH (free)
- Ester (-Ome)
- -NH2
- -NH-Me
- Active ester (NHS; TFP; PFP)
- Dye and fluorescent (by conjugation)
- Biotin
- FITC
- 5-FAM (5,6-FAM)
- Dansyl-
- TAMTA-
- MCA-
- Rhodamine
- Acetylation (Lys)
- Methylation (Arg)
- Phosphorylation (Ser, Thr, Tyr)
- Lipidation
- Glycosylation
- SUMOylation
- Ubiquitination
- 1H – D
- 12C – 13C
- 14N – 15N
- 13C, 15N – Lys
- 13C, 15N – Arg
- 13C, 15N – Ala
- 13C, 15N – Ile
- 13C, 15N – Leu
- 13C, 15N – Pro
- 13C, 15N – Phe
- 13C, 15N – Val
- N-linked glycopeptide synthesis
- O-linked glycopeptide synthesis
- C-linked glycopeptide synthesis
- S-linked glycopeptide synthesis
Beyond side-chain and backbone customization, we seamlessly integrate unnatural amino acids into sequences—expanding chemical space and unlocking new therapeutic possibilities.
For more information on our catalogue of unnatural amino acid products (500+), please CONTACT US.
Cyclic & Macrocyclic Peptide Expertise
Cyclization is a proven approach to improve peptide potency, stability, and target engagement. PeptARx, Aragen’s integrated peptide platform, offers end-to-end capabilities for cyclic and macrocyclic peptides—covering molecular design, synthesis, analytical characterization, and scale-up to advance complex peptide programs.
With deep expertise in macrocyclization, delivering more than 2,500 cyclic peptides annually across a wide range of structural complexities and design requirements.
- Lactam cyclization (mono‑ and bi‑cyclic)
- Lactone formation
- Disulfide bridge formation (single, double, triple)
- Thioether cyclization (mono‑ and bi‑cyclic)
- Click‑based cyclization
- Ring‑closing metathesis (RCM)
- Metal‑catalyzed C–C bond formation (Suzuki, Heck, olefin metathesis)
- Allyl/Alloc, Dde, Mtt, and Pmb protecting groups
- Controlled formation of multiple bridges and complex cyclic architectures
- Head-to-tail
- Head-to-side chain
- Side chain-to-side chain
- Side chain-to-tail
Aragen’s Multi‑Chemistry Cyclic Peptides with Diverse Conjugations
Cyclic Peptides Synthesized at Aragen
Library Synthesis & Parallelization (High-Throughput Discovery)
Coupled with robust analytical workflows, we consistently deliver peptides at exceptional purity—up to 99.9%—meeting stringent research and development standards.
Our team has experience producing linear, cyclic and modified peptides across diverse discovery programmes.
- Tooling: Automated synthesizers (CEM MultiPep 2, Liberty Blue 2.0; Biotage Alstra; SYMPHONY® X-24; PTI Prelude); 48-station SiliCycle block.
- Approach: Parallel & sequential synthesis; microwaveassisted coupling; combined automated/manual strategies for long or difficult peptides.
- Outcome: Crude-to-pure workflows with in-process LCMS/HPLC checks can support iterative synthesis and purification, depending on project requirements.
Advanced Peptide Synthesis
We support the following advanced peptides.
- Ligated Peptide
- Branched Peptides
- Dendrimers
- Peptide Nucleic Acids (PNA)
- Peptoid
- Peptidomimetics, and more
Specialized Reactions on Solid Support
- Suzuki Coupling
- Sonogashira Coupling
- Heck Reaction
- Reductive Amination
- Reduction/Oxidation, and more
