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Home Small Molecules Discovery Biology Integrated In Vivo Pharmacology Respiratory Diseases

Respiratory Diseases

Asthma, COPD, pulmonary fibrosis, acute respiratory models. Inhalational delivery, lung function assessment, translational biomarkers, and clinical relevance.

Aragen’s respiratory disease platform provides validated preclinical models for developing therapeutics across asthma, COPD, interstitial lung disease, pulmonary fibrosis, acute respiratory distress, and rare pulmonary conditions. Our expertise spans pharmacokinetic assessment of inhalational compounds and mechanistic understanding of respiratory inflammation and remodeling.

Key Model Categories

  • Allergic asthma (OVA-sensitization and challenge)
  • Chronic obstructive pulmonary disease (COPD – LPS, cigarette smoke)
  • Pulmonary fibrosis (bleomycin, silica-induced)
  • Acute respiratory distress (LPS, acid aspiration)
  • Infection-driven respiratory disease (viral, bacterial)

Advanced Capabilities

  • Airway hyperresponsiveness (methacholine challenge)
  • Pulmonary mechanics (FlexiVent or similar)
  • Bronchoalveolar lavage (BAL) analysis
  • Inflammatory cell profiling and cytokine assessment
  • Histopathology with morphometric analysis
  • Gene expression profiling (Th1/Th2/Th17 markers)
  • Inhalational delivery and lung deposition assessment
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