Itch Models

Acute and Chronic Itch Models; Itch-related behaviors in both acute and chronic itch models are video-recorded and quantitatively assessed based on the frequency and duration of responses. Chronic itch models are further supported by histological analysis.

Chloroquine–Induced Pruritus Model

A fast, reproducible, and translatable model for evaluating antihistamine-resistant itch with strong mechanistic relevance. 

Models’ antihistamine-resistant itch, a major unmet clinical need

Reflects chronic pruritus conditions (e.g., atopic dermatitis, systemic itch) 

Mimics clinically relevant chronic itch pathways (MrgprA3-driven)

Oxazolone–Induced Chronic Itch Model

The oxazolone-induced chronic itch model closely mimics atopic dermatitis–like inflammation and persistent itch, offering strong translational relevance to chronic pruritic conditions. It enables simultaneous assessment of skin inflammation, barrier dysfunction, and scratching behavior, making it ideal for evaluating both anti-pruritic and anti-inflammatory therapies. Its reproducible chronic phenotype supports studies on long-term efficacy and disease mechanisms.

Clinically Relevant Endpoints

Non-Evoked Pain Endpoints; Affective component of pain (modified Place Escape/Avoidance Paradigm (m-PEAP) and Conditioned Place Preference (CPP)